Mar 26, 2020

Variant Scientist

  • UCLA Health and David Geffen School of Medicine
  • Los Angeles, CA, USA
Full time

Job Description

ResponsibilitiesThe Department of Pathology and Laboratory Medicine at the University of California, Los Angeles, is seeking a variant scientist to work in the Molecular Diagnostics Laboratories. The incumbent needs to have the ability to curate and interpret germline and somatic variants, and draft reports for clinical findings from high throughput molecular diagnostic testing including exome and cancer panel sequencing. The incumbent will be a key member of a clinical team of clinical laboratory scientists, molecular biologists, medical geneticists, clinical molecular geneticists, molecular pathologists and bioinformaticians working together to analyze and report molecular results based on our high throughput sequencing assays. The successful applicant will operate in three major areas: (1) clinical testing: participate in the review of patient clinical notes and sequencing data from high-complexity tests such as Clinical Exome Sequencing. the Solid Tumor Sequencing Panel, the Hematologic Malignancies Sequencing Panel; (2) variant curation and reporting: perform variant curation and interpretation, draft clinical reports; develop SOPs for variant curation and reclassification; (3) research and development: participate in variant submission to public databases, test development and clinical research projects. *This position is based on the UCLA campus in Westwood. This is not a remote position. QualificationsA Ph.D. degree in genetics (e.g. human genetics, molecular genetics, neurogenetics) or cancer-related fields (e.g. cancer cell biology, cellular and molecular pathology, molecular cancer biology, molecular and medical pharmacology) is preferred. Background and expertise in cancer genetics, human genetics and cancer biology will be strongly preferred. Candidates with a Master’s degree in molecular biology, genetics, or other related fields may be considered. Though laboratory techniques are not physically performed, the incumbent must understand the molecular biology of laboratory genetics and genomics (e.g. target capture/amplification and massively parallel sequencing). Excellent communication and writing skills required. Strong ability to collaborate with teams of clinicians, research scientists, and external collaborators required. Exhibits scientific creativity and routinely demonstrates independent thought. Computer fluency is required (e.g. MS Excel, IGV, UCSC/COSMIC genome browsers). Computer programming (e.g. R/SAS/Perl/Python), regex, database design, and/or bioinformatics experience would be a plus. Under the general supervision and direction of the Manager of Molecular Pathology and in collaboration with appropriate faculty, the Clinical Specialist is expected to work in a self-directed manner to complete assignments and achieve departmental goals. Performs established duties under the direction of the Manager of Molecular Pathology, who may adjust duties as dictated by needs. Works as part of a team (with representatives from management, faculty, residents, staff, and students) to periodically assess performance of the department and identify opportunities for improvement. Recommendations may be generated by the team. Incumbent is expected to perform independently on a day-to-day basis. Manager meets periodically with incumbent to review progress and performance. May be assigned other duties within the department by the Manager of Molecular Pathology. UCLA is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected Veteran status. 74514636.jpgi?e=se&tv=pixel_tracker&p=web&aid=uclahealth&se_ca=misc&se_ac=impression&se_la=1944